Indomethacin

Inhibits COX-1 and COX-2

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Indomethacin

Inhibits COX-1 and COX-2

1 g
Catalog #73942
37 USD

Overview

Indomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.). Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 µM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.).

DIFFERENTIATION
· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).

· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).

CANCER RESEARCH

· Inhibits growth of mouse mammary tumors (Fulton).

· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).
Alternative Names:
Indocin
CAS Number:
53-86-1
Chemical Formula:
C₁₉H₁₆ClNO face="Cambria Math">₄
Molecular Weight:
357.8 g/mol
Purity:
≥ 99%
Pathway:
NF-κB
Target:
COX-1

Scientific Resources

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.