Human Recombinant FGF-6

Fibroblast growth factor 6
Catalog #
78184_C
Fibroblast growth factor 6
From: 1,764 USD

Overview

Fibroblast growth factor 6 (FGF-6) is a heparin-binding member of the FGF family, regulators of cell proliferation, differentiation, and function. FGF-6 binds and signals through the FGF receptors 1c, 2c, and 4 (Ornitz et al.). FGF-6 is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells (Asada et al.; Pizette et al.; Ropiquet et al.). FGF-6 is primarily expressed in epithelial and mesenchymal cell lineages. During development, FGF-6 is expressed in skeletal muscle, consistent with its role in muscle differentiation and regeneration (Floss et al.). FGF-6 has also been shown to promote chondrogenesis in embryonic somites in conjunction with transforming growth factor beta 2 (TGF-β2; Grass et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Fibroblast growth factor 6, HBGF-6, Heparin-binding growth factor 6, Heparin secretory-transforming protein 2, HST-2, HSTF-2
Cell Type
Endothelial Cells, Fibroblasts, Mesenchymal Stem and Progenitor Cells, Prostate Cells
Species
Human
Area of Interest
Endothelial Cell Biology, Stem Cell Biology
Molecular Weight
18.9 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant FGF-6
Catalog #
78184.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-6
Catalog #
78184.1
Lot #
All
Language
English

Educational Materials (4)

Brochure
Reliable Antibodies for Your Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Directed Differentiation of Pluripotent Stem Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-6 was tested by its ability to promote proliferation of NR6R-3T3 cells in the presence of 1 μg heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.00442 ng/mL. (B) 1 μg of Human Recombinant FGF-6 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-6 has a predicted molecular mass of 18.9 kDa.

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