A 83-01
Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
Overview
A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.).
MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
Alternative Names
Not applicable
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Maintenance, Reprogramming
Area of Interest
Stem Cell Biology
CAS Number
909910-43-6
Chemical Formula
C₂₅H₁₉N₅S
Molecular Weight
421.5 g/mol
Purity
≥ 95%
Pathway
Activin/Nodal/TGFβ
Target
ALK5
Related Products
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Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
A 83-01
|
Catalog # 72022, 72024, 100-0245 |
Lot # All |
Language English |
|
Document Type
Safety Data Sheet
|
Product Name
A 83-01
|
Catalog # 72022, 72024, 100-0245 |
Lot # All |
Language English |
Educational Materials(5)
Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for
Human Pluripotent Stem Cell Research
Workflow Stages for
hPSC-Derived Neural Cell Research
Workflow Stages for
hPSC-Derived Mesoderm Cell Research
Workflow Stages for
Mouse Pluripotent Stem Cell Research
Legal Statement:
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
