A 83-01
Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
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A 83-01 -
A 83-01 -
Label for A 83-01 -
Label for A 83-01 -
Label for A 83-01
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Overview
A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.).
MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
Alternative Names:
Not applicable
CAS Number:
909910-43-6
Chemical Formula:
C₂₅H₁₉N₅S
Molecular Weight:
421.5 g/mol
Purity:
≥ 95%
Pathway:
Activin/Nodal/TGFβ
Target:
ALK5
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Activin/BMP/TGF-β pathway inhibitor; Inhibits ALK5
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