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A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.).
MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
Lot# 1000028286 or higher for 72022 | Lot# 1000028287 or higher for 72024 | Lot# 1000027271 or higher for 100-0245 | Lot# 1000103072 or higher for 100-1041
Lot# 1000028285 or lower for 72022 | Lot# 1000028286 or lower for 72024 | Lot# 1000027270 or lower for 100-0245 | Lot# 1000103071 or lower for 100-1041
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.