A 83-01

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
Catalog #
72022_C
Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
From: 70 USD

Overview

A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.).

MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).

REPROGRAMMING
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).

DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
Alternative Names
Not applicable
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Maintenance, Reprogramming
Area of Interest
Stem Cell Biology
CAS Number
909910-43-6
Chemical Formula
C₂₅H₁₉NS
Molecular Weight
421.5 g/mol
Purity
≥ 95%
Pathway
Activin/Nodal/TGFβ
Target
ALK5

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
A 83-01
Catalog #
72022, 72024, 100-0245
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
A 83-01
Catalog #
72022, 72024, 100-0245
Lot #
All
Language
English

Educational Materials(5)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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