Human Recombinant Oncostatin M

Oncostatin M

Human Recombinant Oncostatin M

Oncostatin M

From: 189 USD
Catalog #
78094_C
Oncostatin M

Overview

Oncostatin M (OSM) is a member of interleukin 6 (IL-6) family of cytokines and bears close resemblance to leukemia-inhibitory factor (LIF) and granulocyte colony-stimulating factor (G-CSF) in amino acid sequence and its modulation of differentiation in a variety of cell types (Rose & Bruce). OSM signals through type I receptor (consisting of gp130 and LIF receptor (LIFR)) and type II receptor (consisting of gp130 and OSM receptor (OSMR)), which eventually activate the JAK/STAT pathway (Auguste et al.; Gómez-Lechón). OSM is primarily produced by activated T cells and monocytes, and also by activated macrophages, neutrophils, mast cells, and dendritic cells. OSM is also produced within the bone microenvironment by cells of both hematopoietic and mesenchymal origin including osteocytes and osteoblasts. OSM is involved in differentiation, cell proliferation, hematopoiesis, and inflammation, and also has been shown to have implications in liver development, bone formation and resorption (Sims & Quinn; Tanaka & Miyajima).
Subtype
Cytokines
Alternative Names
OSM
Cell Type
Airway Cells, B Cells, Hematopoietic Stem and Progenitor Cells, Intestinal Cells, Lymphocytes, Neurons, T Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Immunology, Neuroscience, Stem Cell Biology
Molecular Weight
25.9 kDa
Purity
≥ 95 %

Data Figures

(A) The biological activity of Human Recombinant Oncostatin M was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 10 ng/mL. (B) 2 μg of Human Recombinant Oncostatin M was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Oncostatin M has a predicted molecular mass of 25.9 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78094, 78094.1, 78094.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78094, 78094.1, 78094.2
Lot #
All
Language
English

Resources and Publications

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