Human Recombinant IL-15

Interleukin 15
Catalog #
78031_C
Interleukin 15
From: 185 USD

Overview

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra, the high-affinity receptor for IL-15, as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naive CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.).
Subtype
Cytokines
Alternative Names
IL-T, Interleukin-15
Cell Type
Hematopoietic Stem and Progenitor Cells, Lymphocytes, NK Cells
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
12.9 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-15
Catalog #
78031, 78031.1, 78031.3
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-15
Catalog #
78031, 78031.1, 78031.3
Lot #
All
Language
English

Educational Materials (3)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Tools For Your Immunology Research
Wallchart
Human Immune Cytokines

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-15 was tested by its ability to promote the proliferation of CTLL-2 cells growing in the presence of other cytokines and stimuli. Cell proliferation was measured after 65 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.13 - 0.19 ng/mL.
(B) 1 ug of Human Recombinant IL-15 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-15 has a predicted molecular mass of 12.9 kDa.

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