Naïve and Ground-State Pluripotency

Human pluripotent stem cells (hPSCs) can be maintained along a spectrum of different pluripotent states. In vitro, different cell culture media with specific combinations of cytokines or small molecules have been shown to maintain cells in either a naïve or primed pluripotent state. Multiple research groups have recently identified different culture conditions capable of shifting and maintaining hPSCs toward the "ground" or "naïve" state and away from the traditional primed state of hPSCs.

Explore the resources below for information on the ground state hPSC research.

hPSC Survey Report

Learn about the latest insights and trends in hPSC research, such as irreproducibility and quality control, and how to address them in your research.

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Fluorescent microscopy of dividing human pluripotent stem cells

Quality Control for Pluripotent Stem Cells

Get to know the key quality attributes of hPSC cultures, including techniques for maintaining and assessing genomic integrity, pluripotency, and morphology.

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Light microscopy of human pluripotent stem cell colonies

Webinar: Naïve-Like PSC Generation and Maintenance

Hear Dr. Arwen Hunter describe the use of RSeT™ medium to revert primed hPSCs and maintain them in the ground or naïve-like state.

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Panelists from Nature Research Round Table: Challenges in Ensuring hPSC Quality

Panel: Challenges in Ensuring hPSC Quality

Hear global experts discuss key issues impacting the use of human pluripotent stem cells in this series of webinars provided in partnership with Nature Research.

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Fluorescent microscopy of human pluripotent stem cell colony

Introduction to Pluripotent Stem Cells

Get an overview on in vitro hPSC culture and derivation for research use, as well as insights into the role of hPSCs for clinical applications such as drug development and cell therapy.

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