Naïve and Ground-State Pluripotency

Human pluripotent stem cells (hPSCs) can be maintained along a spectrum of different pluripotent states. In vitro, different cell culture media with specific combinations of cytokines or small molecules have been shown to maintain cells in either a naïve or primed pluripotent state. Multiple research groups have recently identified different culture conditions capable of shifting and maintaining hPSCs toward the "ground" or "naïve" state and away from the traditional primed state of hPSCs.

Explore the resources below for information on the ground state hPSC research.

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