Hematopoietic Stem and Progenitor Cell Research
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Ongoing research on hematopoietic stem and progenitor cells (HSPCs) is directed toward the identification, isolation, and characterization of the primitive cell types that mediate rapid and/or sustained hematological recovery after cytoreductive therapy and transplantation. HSPCs are also being investigated in cell-based therapies for non-hematopoietic disorders.
The review below provides an overview of the current status of HSPC research with a focus on (i) assays used to detect and enumerate human and mouse stem and progenitor cells, (ii) phenotypic markers and methods used for their identification and isolation, and (iii) culture systems used to amplify stem and progenitor cells or to promote their differentiation in order to produce large numbers of mature blood cells for transfusion.
Hematopoietic Stem and Progenitor Cell Isolation, Culture, and Assays
Read an overview of HSPC research with a focus on methods of isolation, culture, and assays used to detect and enumerate HSPCs.