Valproic Acid (Sodium Salt)

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

Valproic Acid (Sodium Salt)

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

From: 48 USD
Catalog #
72292_C
Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

Overview

Valproic Acid (VPA) is a short-chain fatty acid that acts as an epigenetic modifier by inhibiting Histone Deacetylases (HDACs) with IC₅₀ values ranging from 0.4 - 3 mM. VPA can also increase γ­aminobutyric acid (GABA) levels via inhibition of enzymes involved in GABA metabolism. Other effects include depletion of cellular inositol by inhibiting myo-inositol-1-phosphate synthase. (Gottlicher et al., Khan et al., Phiel et al., Rosenberg)

REPROGRAMMING
· Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Tranylcypromine, 3-Deazaneplanocin A, and E-616452 (Hou et al.).
· Increases the reprogramming efficiency of mouse embryonic fibroblasts to iPS cells (Huangfu et al. 2008a).
· Promotes reprogramming of human fibroblasts to iPS cells using only 2 factors, OCT4 and SOX2 (Huangfu et al. 2008b).
· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Gö6983 and Y-27632 (Hu et al.).

MAINTENANCE AND SELF-RENEWAL
· Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Chaurasia et al.).
· Promotes the proliferation and self-renewal of human and mouse hematopoietic progenitor cells (Bug et al., De Felice et al.).

DIFFERENTIATION
· Promotes differentiation of neurons and suppresses differentiation of astrocytes and oligodendrocytes from rat neural progenitor cells (Hsieh et al., Jung et al.).
· Promotes osteogenic differentiation of human mesenchymal stem cells (Cho et al.).
Alternative Names
2-Propylvaleric acid; Sodium valproate; VPA
Cell Type
Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Neurons, Osteoblasts, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Expansion, Maintenance, Reprogramming
Area of Interest
Neuroscience
CAS Number
1069-66-5
Chemical Formula
C₈H₁₅O₂ · Na
Molecular Weight
166.2 g/mol
Purity
≥ 95%
Pathway
Epigenetic
Target
HDAC

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
72292, 100-1053
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
72292
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1053
Lot #
All
Language
English

Product Applications

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