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Human Recombinant TGF-beta 3

Transforming growth factor beta 3

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From: 185 USD

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Transforming growth factor beta 3
From: 185 USD

Overview

Transforming growth factor (TGF) beta 3 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. TGF-beta 3 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell et al.). TGF-beta 3 enhances glycosaminoglycan production by mesenchymal stromal cells, stimulates scar-free healing, and improves glucose tolerance and phenotypic changes in adipocyte morphology (Hall et al.; Holton et al.). TGF-beta 3 induces proliferation of posterofrontal suture-derived mesenchymal stromal cells, and stimulates expression of fibroblast growth factors 2 and 18 (James et al.).
Alternative Names:
ARVD, FLJ16571, TGFB3, TGF-b3, Transforming growth factor beta-3
Cell Type:
Mesenchymal Stem and Progenitor Cells; Mesenchymal Cells, PSC-Derived
Area of Interest:
Stem Cell Biology
Molecular Weight:
12.9 kDa monomer; 25.7 kDa dimer
Purity:
≥ 95%

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant TGF-beta 3 was tested by its ability to inhibit proliferation of HT-2 cells in the presence of IL-4. Inhibition of cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is 0.0445 ng/mL. (B) 1 μg of Human Recombinant TGF-beta 3 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.