Human Recombinant IL-7

Interleukin 7

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Interleukin 7
From: 202 USD

Overview

Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).
Alternative Names:
Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Cell Type:
Hematopoietic Stem and Progenitor Cells; Lymphocytes
Species:
Human
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
17.5 kDa
Purity:
≥ 95%

Scientific Resources

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(3)

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-7 was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.06 - 0.09 ng/mL.
(B) 1 μg of Human Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7 has a predicted molecular mass of 17.5 kDa.

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