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Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch et al.). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei & Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete et al.). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson et al.). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang et al.). This product is animal component-free (ACF).
Subtype
Cytokines
Alternative Names
Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin Neu differentiation factor, HRG, HRG1, HRG1-beta 1, Neuregulin-1, NRG1, NRG1-beta 1, Sensory and motor neuron-derived factor
Cell Type
Cancer Cells and Cell Lines, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons
Figure 1. Biological Activity and Molecular Mass of Human Recombinant Heregulin-beta 1, ACF
(A) The biological activity of Human Recombinant Heregulin-beta 1, ACF was tested by its ability to induce MAP/ERK signaling in transfected MCF-7 cells using a luciferase reporter assay. Firefly luciferase activity is normalized to the control Renilla luciferase activity. The EC50 is defined as the effective concentration of the growth factor at which Heregulin-beta 1 response is at 50% of maximum. The EC50 in the above example is 37.9 pM (0.28 ng/mL).
(B) 3 μg of Human Recombinant Heregulin-beta 1, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Heregulin-beta 1, ACF has a predicted molecular mass of 7.5 kDa.
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