Mouse Recombinant IL-7

Interleukin 7

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Interleukin 7
From: 202 USD

Overview

Interleukin 7 (IL-7) is a member of the type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh), and provides signals to promote survival, proliferation, and differentiation during B cell development (Clark et al.; Corfe & Paige).
Alternative Names:
Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Cell Type:
Hematopoietic Stem and Progenitor Cells; Lymphocytes
Species:
Mouse
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
15 kDa
Purity:
≥ 95%

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(3)

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Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-7 was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.4 ng/mL.
(B) 5 μg of Mouse Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-7 has a predicted molecular mass of 15 kDa but migrates to an apparent molecular mass of ~24 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.