DAPT

Notch pathway inhibitor; Inhibits γ-secretase

DAPT

Notch pathway inhibitor; Inhibits γ-secretase

From: 177 USD
Catalog #
72082_C
Notch pathway inhibitor; Inhibits γ-secretase

Overview

DAPT is an inhibitor of the γ-secretase complex. Notch is a key target of γ-secretase, therefore DAPT indirectly inhibits the Notch pathway. Other targets of γ-secretase that would be influenced by DAPT include amyloid precursor protein, E-cadherin, and ErbB4. (Dovey et al.).

MAINTENANCE AND SELF-RENEWAL
· Reduces colony-forming efficiency of mouse neural stem cells (Androutsellis-Theotokis et al.).
· Enhances radiation-induced cell death of glioma stem cells (Wang et al.).

DIFFERENTIATION
· Promotes differentiation of nociceptors from human pluripotent stem cells, in combination with several other small molecules (Chambers et al.).
· Promotes differentiation of neurons from human and mouse embryonic stem (ES) cells (Crawford and Roelink, Elkabetz et al.).
· Promotes differentiation of retinal pigment epithelium from mouse ES cells (Osakada et al.).
· Promotes differentiation of pancreatic cells from human pluripotent stem cells (D'Amour et al.).

CANCER RESEARCH
· Reduces mammosphere-forming efficiency of breast cancer cell lines and ductal carcinoma in situ cells (Farnie et al., Harrison et al.).
Alternative Names
GSI-IX; LY-374973
Cell Type
Cancer Cells and Cell Lines, Endoderm, PSC-Derived, Mammary Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Pancreatic Cells, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Cancer
CAS Number
208255-80-5
Chemical Formula
C₂₃H₂₆F₂N₂O₄
Molecular Weight
432.5 g/mol
Purity
≥ 95%
Pathway
Notch
Target
γ-Secretase

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
DAPT
Catalog #
100-1046, 72082
Lot #
All
Language
English
Product Name
DAPT
Catalog #
72082
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
DAPT
Catalog #
100-1046
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
DAPT
Catalog #
72082
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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