Retinoid pathway activator; Activates retinoic acid receptor (RAR) alpha
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· Promotes reprogramming of somatic cells to induced pluripotent stem cells (Wang et al.).
· Induces differentiation of human induced pluripotent stem cells into intermediate mesoderm, in combination with the GSK3β inhibitor CHIR99021 (Araoka et al.).
· Inhibits tumor cell proliferation and survival signaling pathways, and induces apoptosis, leading to inhibition of mouse mammary tumor virus (MMTV)-neu- and MMTV-wnt1-induced mammary gland hyperplasia (Lu et al.).
· Inhibits tumor growth in MMTV-Myc mice (Bosch et al.).
· Inhibits endometrial cancer cell proliferation (Cheng et al.).
· Induces differentiation in acute promyelocytic leukemia cells (Gianní et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Resources and Publications
Educational Materials (2)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.