Mouse Recombinant IL-7

Interleukin 7

Mouse Recombinant IL-7

Interleukin 7

From: 223 USD
Catalog #
78054_C
Interleukin 7

Overview

Interleukin 7 (IL-7) is a member of the type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh), and provides signals to promote survival, proliferation, and differentiation during B cell development (Clark et al.; Corfe & Paige).
Subtype
Cytokines
Alternative Names
Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Cell Type
Hematopoietic Stem and Progenitor Cells, Lymphocytes
Species
Mouse
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
15 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Mouse Recombinant IL-7 was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.4 ng/mL.
(B) 5 μg of Mouse Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-7 has a predicted molecular mass of 15 kDa but migrates to an apparent molecular mass of ~24 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78054, 78054.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78054, 78054.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Resources and Publications

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