Directed Differentiation and Disease Modeling

Human pluripotent stem cell (hPSC)-based models hold tremendous potential for the study of human development and disease. hPSC-derived cells provide a physiologically relevant model for drug discovery, cell therapy validation and disease research.

Explore the resources below to support your disease modeling studies using hPSCs.

hPSC Survey Report

Learn about the latest insights and trends in hPSC research, such as irreproducibility and quality control, and how to address them in your research.

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Panelists from Nature Research Round Table: Challenges in Ensuring hPSC Quality

Panel: Challenges in Ensuring hPSC Quality

Hear global experts discuss key issues impacting the use of human pluripotent stem cells in this series of webinars provided in partnership with Nature Research.

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Fluorescent microscopy of human pluripotent stem cell colony

Introduction to Pluripotent Stem Cells

Get an overview on in vitro hPSC culture and derivation for research use, as well as insights into the role of hPSCs for clinical applications such as drug development and cell therapy.

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Fluorescent microscopy of dividing human pluripotent stem cells

Quality Control for Pluripotent Stem Cells

Get to know the key quality attributes of hPSC cultures, including techniques for maintaining and assessing genomic integrity, pluripotency, and morphology.

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Immunohistological staining of progenitors of the three embryonic germ layers

Assessing Pluripotency

High-quality hPSCs should maintain the potential to differentiate into progenitors of all three germ lineages. Learn about pluripotency and optimized assays for in vitro validation.

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