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Directed Differentiation and Disease Modeling

Human pluripotent stem cell (hPSC)-based models hold tremendous potential for the study of human development and disease. hPSC-derived cells provide a physiologically relevant model for drug discovery, cell therapy validation and disease research.

Explore the resources below to support your disease modeling studies using hPSCs.

Derivation and Applications of Human Pluripotent Stem Cells
Derivation and Applications of Human Pluripotent Stem Cells
Overview of the derivation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs)
Building Three-Dimensional Human Brain Organoids
Building Three-Dimensional Human Brain Organoids
Overview of brain organogenesis and the applications of brain organoids in studying the development and maturation of the nervous system
SnapShot: GI Tract Development
SnapShot: GI Tract Development
Overview of gastrointestinal tract specification signals and summary of pancreatic cellular hierarchy and cell markers
Cell-Reprogramming Technology and Neuroscience
Cell-Reprogramming Technology and Neuroscience
Details on human iPSC-derived models of neuropsychiatric and neurodegenerative disorders
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Overview of signaling pathways and small molecules in pluripotent stem cell research
Directed Differentiation of Pluripotent Stem Cells
Directed Differentiation of Pluripotent Stem Cells
Strategies for differentiating ES and iPS cells into ectoderm, endoderm or mesoderm
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  1. Wallchart 6 items
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  1. Cell Culture Media and Supplements 5 items
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  1. Angiogenic Cell Research 1 item
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  3. Cell Line Development 1 item
  4. Disease Modeling 3 items
  5. Drug Discovery and Toxicity Testing 3 items
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  10. Stem Cell Biology 6 items
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  1. AggreWell 1 item
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  1. Airway Cells 1 item
  2. Cardiomyocytes, PSC-Derived 1 item
  3. Endoderm, PSC-Derived 2 items
  4. Endothelial Cells, PSC-Derived 1 item
  5. Epithelial Cells, PSC-Derived 1 item
  6. Hematopoietic Cells, PSC-Derived 1 item
  7. Hepatic Cells 1 item
  8. Hepatic Cells, PSC-Derived 1 item
  9. Intestinal Cells 1 item
  10. Mesenchymal Cells, PSC-Derived 1 item
  11. Mesoderm, PSC-Derived 1 item
  12. Neural Cells, PSC-Derived 3 items
  13. Neural Stem and Progenitor Cells 1 item
  14. Pancreatic Cells 1 item
  15. Pluripotent Stem Cells 5 items
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