Directed Differentiation and Disease Modeling

Human pluripotent stem cell (hPSC)-based models hold tremendous potential for the study of human development and disease. hPSC-derived cells provide a physiologically relevant model for drug discovery, cell therapy validation and disease research.

Explore the resources below to support your disease modeling studies using hPSCs.

Overview of the derivation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs)
Overview of brain organogenesis and the applications of brain organoids in studying the development and maturation of the nervous system
Overview of gastrointestinal tract specification signals and summary of pancreatic cellular hierarchy and cell markers
Details on human iPSC-derived models of neuropsychiatric and neurodegenerative disorders
Overview of signaling pathways and small molecules in pluripotent stem cell research
Strategies for differentiating ES and iPS cells into ectoderm, endoderm or mesoderm

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