Directed Differentiation and Disease Modeling
Human pluripotent stem cell (hPSC)-based models hold tremendous potential for the study of human development and disease. hPSC-derived cells provide a physiologically relevant model for drug discovery, cell therapy validation and disease research.
Explore the resources below to support your disease modeling studies using hPSCs.
Highly Efficient Single-Cell Human Pluripotent Stem Cell Cloning and Robust Cardiomyocyte Differentiation
Recorded during the ISSCR 2017 Innovation Showcase in Boston, this tutorial highlights human pluripotent stem cell (hPSC) gene-editing and cardiac differentiation workflows using the CloneR™ supplement and the STEMdiff™ Cardiomyocyte System. This talk is presented by STEMCELL Technologies’ Dr. Adam Hirst, scientist for pluripotent stem cell biology, and Dr. Vincenzo Macri, senior scientist for cardiomyocyte stem cell biology.
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Directed Differentiation of Pluripotent Stem Cells
Strategies for differentiating ES and iPS cells into ectoderm, endoderm or mesoderm -
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Overview of signaling pathways and small molecules in pluripotent stem cell research -
Cell-Reprogramming Technology and Neuroscience
Details on human iPSC-derived models of neuropsychiatric and neurodegenerative disorders -
SnapShot: GI Tract Development
Overview of gastrointestinal tract specification signals and summary of pancreatic cellular hierarchy and cell markers -
Building Three-Dimensional Human Brain Organoids
Overview of brain organogenesis and the applications of brain organoids in studying the development and maturation of the nervous system -
Derivation and Applications of Human Pluripotent Stem Cells
Overview of the derivation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs)