Liver Organoids

The liver is a vital organ involved in a wide range of processes such as detoxification, protein synthesis, metabolism, and hormone production. Despite an astounding regenerative capacity in vivo, expansion of liver cells in vitro has remained a challenge. Growth of the hepatic epithelium as organoids provides researchers with a stable population of liver cells for research in a variety of fields including liver biology, disease modeling and toxicity screening.

Explore the resources below for information on the expansion and maintenance of hepatic epithelial cells as organoids.

Key Applications of Hepatic Organoids

Disease Modeling and Cancer Research

Hepatic Cell Biology

Dorrell C, et al. (2014) The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar. Stem Cell Res. 13(2): 275-83.
Tarlow BD, et al. (2014) Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury. Hepatology. 60(1): 278-89.
Yimlamai D, et al. (2014) Hippo pathway activity influences liver cell fate. Cell. 157(6): 1324-38.
Kruitwagen HS, et al. (2018) DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells. Stem Cells Dev.

Organoids in Multi-Lineage Model Systems