· Increases the reprogramming efficiency of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells (Huangfu et al.).
· Resets epigenetic memory in mouse iPS cells, in combination with 5-Azacytidine (Kim et al.).
·Increases the efficiency of cloned mouse embryo development by somatic cell nuclear transfer (Kishigami et al.).
MAINTENANCE AND SELF-RENEWAL
· Prevents dedifferentiation of primary rat hepatocytes in culture, maintaining liver-specific cellular functions (Henkens et al.).
· Promotes differentiation of hepatocytes from human mesenchymal stem cells (Snykers et al.).
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