Quercetin

mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

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mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases
From: 22 USD

Overview

Quercetin inhibits phosphoinositide 3-kinase isoforms (beta: IC50 = 5.4 µM, gamma: IC50 = 2.4 µM, delta: IC50 = 3.0 µM) and SRC kinases but only shows slight inhibitory activity against serine/threonine kinases ERK1/2 and p38 alpha, as well as protein kinase C (Navarro-Nunez et al.).

REPROGRAMMING
· Stimulates glycolytic metabolism and promotes reprogramming of somatic cells (Zhang et al.).
· Enhances reprogramming of human primary somatic cells to induced pluripotent stem cells (Zhu et al.).


CANCER RESEARCH
· Induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation (Triantafyllou et al.).
· Promotes apoptosis of glioblastoma cells when used together with temozolomide (Sang et al.).
· Reduces tumorigenicity of pancreatic cancer cells (Fan et al.).
Alternative Names:
Not applicable
CAS Number:
117-39-5
Chemical Formula:
C₁₅H₁₀O
"
Molecular Weight:
302.2 g/mol
Purity:
≥ 95%
Pathway:
mTOR; NF-κB; PI3K/AKT; Tyrosine Kinase
Target:
PI3K; SRC

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.