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Quercetin

mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

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Quercetin

mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

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mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases
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Overview

Quercetin inhibits phosphoinositide 3-kinase isoforms (beta: IC50 = 5.4 µM; gamma: IC50 = 2.4 µM; delta: IC50 = 3.0 µM) and SRC kinases but only shows slight inhibitory activity against serine/threonine kinases ERK1/2 and p38 alpha, as well as protein kinase C (Navarro-Nunez et al.).

REPROGRAMMING
⦁ Stimulates glycolytic metabolism and promotes reprogramming of somatic cells (Zhang et al.).
⦁ Enhances reprogramming of human primary somatic cells to induced pluripotent stem cells (Zhu et al.).

CANCER RESEARCH
⦁ Induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation (Triantafyllou et al.).
⦁ Promotes apoptosis of glioblastoma cells when used together with temozolomide (Sang et al.).
⦁ Reduces tumorigenicity of pancreatic cancer cells (Fan et al.).
Cell Type
Brain Tumor Stem Cells, Cancer Cells and Cell Lines, Pancreatic Cells, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Reprogramming
Area of Interest
Cancer, Disease Modeling, Stem Cell Biology
CAS Number
849061-97-8
Chemical Formula
C₁₅H₁₀O₇ • XH₂O
Purity
≥ 95%
Pathway
mTOR, NF-κB, PI3K/AKT, Tyrosine Kinase
Target
PI3K, SRC

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Quercetin (Hydrate)
Catalog #
73934, 73932
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Quercetin (Hydrate)
Catalog #
73934, 73932
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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