Quercetin

mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

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Quercetin (Hydrate)

mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

5 g
Catalog #73932
23 USD

Quercetin (Hydrate)

mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

10 g
Catalog #73934
38 USD

Overview

Quercetin inhibits phosphoinositide 3-kinase isoforms (beta: IC50 = 5.4 µM; gamma: IC50 = 2.4 µM; delta: IC50 = 3.0 µM) and SRC kinases but only shows slight inhibitory activity against serine/threonine kinases ERK1/2 and p38 alpha, as well as protein kinase C (Navarro-Nunez et al.).

REPROGRAMMING
· Stimulates glycolytic metabolism and promotes reprogramming of somatic cells (Zhang et al.).
· Enhances reprogramming of human primary somatic cells to induced pluripotent stem cells (Zhu et al.).

CANCER RESEARCH
· Induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation (Triantafyllou et al.).
· Promotes apoptosis of glioblastoma cells when used together with temozolomide (Sang et al.).
· Reduces tumorigenicity of pancreatic cancer cells (Fan et al.).
Alternative Names:
Not applicable
CAS Number:
849061-97-8
Chemical Formula:
C₁₅H₁₀O • XHO
Molecular Weight:
302.2 g/mol
Purity:
≥ 95%
Pathway:
mTOR; NF-κB; PI3K/AKT; Tyrosine Kinase
Target:
PI3K; SRC

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