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Human Recombinant GDF-5

Growth differentiation factor 5

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Human Recombinant GDF-5

Growth differentiation factor 5

From: 310 USD
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Growth differentiation factor 5
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Overview

Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) subclass of the transforming growth factor beta (TGF-β) superfamily. It binds a receptor complex comprising BMPR1B and BMPR2, which then activates the SMAD signaling pathway (Carreira et al.; Nishitoh et al.; Osório et al.). GDF-5 enhances chondrogenic differentiation of mesenchymal stem cells, skeletogenesis, and dendrite growth during development (Coleman et al.; Francis-West et al.). Studies in rat demonstrated that GDF-5 regulates patterning, neurogenesis, astrogliogenesis, and neuronal specification (Gajavelli et al.; Krieglstein et al.; O’Keeffe et al.).
Subtype
Cytokines
Alternative Names
BMP-14, Bone morphogenic protein 14, CDMP-1, Growth differentiation factor 5
Cell Type
Endoderm, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Molecular Weight
13.7 kDa monomer; 27.4 kDa dimer
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant GDF-5 was tested by its ability to induce alkaline phosphatase production in ATDC-5 cells. Alkaline phosphatase production was measured after 63 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 0.017 μg/mL. (B) 1 μg of Human Recombinant GDF-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant GDF-5
Catalog #
78111.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant GDF-5
Catalog #
78111.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (5)

hPSC-Derived Neural Cell Research
Brochure
hPSC-Derived Neural Cell Research
Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Cell-Reprogramming Technology and Neuroscience
Wallchart
Cell-Reprogramming Technology and Neuroscience
Stem Cell States: Naive to Primed Pluripotency
Wallchart
Stem Cell States: Naive to Primed Pluripotency

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Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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