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Human Recombinant EPO (HEK293-expressed)

Erythropoietin, Fc tag

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Human Recombinant EPO (HEK293-expressed)

Erythropoietin, Fc tag

From: 529 USD
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Erythropoietin, Fc tag
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Overview

The principal physiological regulator of erythropoiesis, Erythropoietin (EPO) is a glycoprotein growth factor that is produced primarily in the kidney in response to hypoxia or anemia. EPO promotes erythropoiesis by binding to a homodimeric cell surface receptor that activates JAK2/STAT5, PI3K/AKT, and MAPK pathways, and stimulates the proliferation and differentiation of erythroid progenitor cells (Jelkmann. Transfus Med Hemother, 2013; Kuhrt & Wojchowski. Blood, 2015). At the carboxy terminus, Human Recombinant EPO (HEK293-expressed) contains a human IgG1 Fc tag.
Subtype
Cytokines
Alternative Names
Epoetin, Erythropoietin, EP
Cell Type
Hematopoietic Stem and Progenitor Cells, Mesoderm, PSC-Derived, Pluripotent Stem Cells
Species
Human
Area of Interest
Stem Cell Biology
Purity
≥ 92%

Data Figures

Figure 1. Biological Activity and Molecular Mass of Human Recombinant EPO (HEK293-expressed)

(A) The biological activity of Human Recombinant EPO (HEK293-expressed) was tested by its ability to promote the proliferation of TF-1 cells. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is ≤ 8 ng/mL. (B) Human Recombinant EPO (HEK293-expressed) was resolved with SDS-PAGE under reducing conditions. Human Recombinant EPO has a predicted molecular mass of 45.1 kDa. The recombinant protein migrates with an apparent molecular mass of 60 - 65 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant EPO (HEK293-expressed)
Catalog #
100-1717, 100-1716
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant EPO (HEK293-expressed)
Catalog #
100-1717
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant EPO (HEK293-expressed)
Catalog #
100-1716
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (9)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
High Affinity Anti-EPO Reagents for Consistent Results
Brochure
High Affinity Anti-EPO Reagents for Consistent Results
Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Human Hematopoietic Stem and Progenitor Cell Phenotyping
Wallchart
Human Hematopoietic Stem and Progenitor Cell Phenotyping
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Identification of Colonies Derived from Human Hematopoietic Progenitors
Wallchart
Identification of Colonies Derived from Human Hematopoietic Progenitors
Serum- and Feeder-Free Differentiation of Erythroid Progenitor Cells from hPSCs
31:39
Webinar
Serum- and Feeder-Free Differentiation of Erythroid Progenitor Cells from hPSCs
A Guide to Erythropoiesis - EPO Signaling and Erythroid Development
40:56
Webinar
A Guide to Erythropoiesis - EPO Signaling and Erythroid Development
Erythropoietin (EPO): Properties, Biological Functions, and Measurement
Mini Review
Erythropoietin (EPO): Properties, Biological Functions, and Measurement

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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