NU7026

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
From: 83 USD

Overview

NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.). NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.).


GENOME EDITING
· Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.).

CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.).
Alternative Names:
LY293646; DNA-PK Inhibitor II
CAS Number:
154447-35-5
Chemical Formula:
C₁₇H₁₅NO₃
Molecular Weight:
281.3 g/mol
Purity:
≥ 95%

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.