Make more informed purchasing decisions with our new product availability and delivery estimate feature, now available on all product pages, in your cart, and during checkout.
Sign In
New to STEMCELL?
Register for an account to quickly and easily purchase products online and for one-click access to all educational content.
Thank you for your interest in this product.
Please provide us with your contact information and your local representative
will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
IBMX is an inhibitor of cyclic nucleotide phosphodiesterases (PDEs; IC₅₀ = 19, 50, 18, 13, 32, 7, and 50 µM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases.
DIFFERENTIATION
· Used in combination with fibroblast growth factor (FGF) 1, dopamine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and forskolin to induce expression of the dopaminergic neuron marker tyrosine hydroxylase in neurons derived from the human NT2 cell line (Iacovitti et al.).
· Used in combination with dexamethasone, insulin, and indomethacin for in vitro induction of adipogenic differentiation of unrestricted somatic stem cells (USSCs), a CD45-negative population of stem cells isolated from human cord blood (Kögler et al.; Pittenger et al.).
· Induces neural differentiation from human umbilical cord blood-derived mesenchymal stem cells (MSCs; Tio et al.).
· Promotes the differentiation of rat neural progenitor cells (NPCs) into functional neurons in vitro (Lepski et al.).
Cell Type
Adipocytes, Mesenchymal Stem and Progenitor Cells, Neural Stem and Progenitor Cells, Neurons
This product is designed for use in the following research area(s) as part
of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we
offer to support each research area.
cAMP pathway activator; Inhibits type 4 cyclic nucleotide phosphodiesterases (PDE4)
Item added to your cart
IBMX
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
