IBMX
cAMP pathway activator; Inhibits cyclic nucleotide phosphodiesterases
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Overview
DIFFERENTIATION
· Used in combination with fibroblast growth factor (FGF) 1, dopamine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and forskolin to induce expression of the dopaminergic neuron marker tyrosine hydroxylase in neurons derived from the human NT2 cell line (Iacovitti et al.).
· Used in combination with dexamethasone, insulin, and indomethacin for in vitro induction of adipogenic differentiation of unrestricted somatic stem cells (USSCs), a CD45-negative population of stem cells isolated from human cord blood (Kögler et al.; Pittenger et al.).
· Induces neural differentiation from human umbilical cord blood-derived mesenchymal stem cells (MSCs; Tio et al.).
· Promotes the differentiation of rat neural progenitor cells (NPCs) into functional neurons in vitro (Lepski et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
