Human Recombinant TPO

Thrombopoietin

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Thrombopoietin
From: 399 USD

Overview

Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and in vivo. TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets in vivo (Bartley et al.; de Sauvage et al.; Foster et al.; Sohma et al.). TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells. It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock & Kaushansky). The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets (Ng et al.).
Alternative Names:
c-MPL ligand, Megakaryocyte colony-stimulating factor, MGDF, MKCSF, ML, MPLLG, THCYT1, THPO
Cell Type:
Hematopoietic Stem and Progenitor Cells; Mesoderm, PSC-Derived; Pluripotent Stem Cells
Species:
Human
Area of Interest:
Stem Cell Biology
Molecular Weight:
36.3 kDa
Purity:
≥ 90%

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Data and Publications

Data

The biological activity of Human Recombinant TPO was tested by its ability to promote the proliferation of MO7e cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 10.2 ng/mL.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.