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Human Recombinant IL-7

Interleukin 7

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From: 190 USD

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Interleukin 7
From: 190 USD

Overview

Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).
Alternative Names:
Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Cell Type:
Hematopoietic Stem and Progenitor Cells; Lymphocytes
Species:
Human
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
17.5 kDa
Purity:
≥ 95%

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(3)

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Data and Publications

Data

(A) The biological activity of Human Recombinant IL-7 was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.06 - 0.09 ng/mL.
(B) 1 μg of Human Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7 has a predicted molecular mass of 17.5 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.