Human Recombinant GDF-5

Growth differentiation factor 5

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Growth differentiation factor 5
From: 197 USD

Overview

Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) subclass of the transforming growth factor beta (TGF-β) superfamily. It binds a receptor complex comprising BMPR1B and BMPR2, which then activates the SMAD signaling pathway (Carreira et al.; Nishitoh et al.; Osório et al.). GDF-5 enhances chondrogenic differentiation of mesenchymal stem cells, skeletogenesis, and dendrite growth during development (Coleman et al.; Francis-West et al.). Studies in rat demonstrated that GDF-5 regulates patterning, neurogenesis, astrogliogenesis, and neuronal specification (Gajavelli et al.; Krieglstein et al.; O’Keeffe et al.).
Alternative Names:
BMP-14, Bone morphogenic protein 14, CDMP-1, Growth differentiation factor 5
Cell Type:
Neural Stem and Progenitor Cells; Endoderm, PSC-Derived
Species:
Human
Area of Interest:
Stem Cell Biology; Neuroscience
Molecular Weight:
13.7 kDa monomer; 27.4 kDa dimer
Purity:
≥ 95%

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant GDF-5 was tested by its ability to induce alkaline phosphatase production in ATDC-5 cells. Alkaline phosphatase production was measured after 63 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 0.017 μg/mL. (B) 1 μg of Human Recombinant GDF-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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