Human Recombinant FGF-16

Fibroblast growth factor 16

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Fibroblast growth factor 16
From: 74 USD

Overview

Fibroblast growth factor 16 (FGF-16) is a heparin-binding member of the FGF family. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGFs act primarily on cells of mesodermal and neuroectodermal origin to regulate diverse physiological functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, and tissue repair (Goldfarb; Green et al.). In vitro, FGF-16 has been shown to promote the proliferation of brown adipocytes and in rat embryos it is predominantly expressed in these cells. FGF-16 has also been shown to play a critical role in embryonic heart development and is thought to play a cardioprotective role after birth (Hotta et al.; Lu et al.; Wang et al.).
Alternative Names:
Fibroblast growth factor 16, Metacarpal 4-5 fusion, MF4
Cell Type:
Adipocytes
Species:
Human
Area of Interest:
Stem Cell Biology
Molecular Weight:
23.6 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-16 was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 20 ng/mL. (B) 2 μg of Human Recombinant FGF-16 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-16 has a predicted molecular mass of 23.6 kDa.

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