Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase
· Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Valproic Acid, Tranylcypromine, and E-616452, by increasing OCT4 expression at later stages of reprogramming (Hou et al.).
· Reactivation of XIST-dependent inactive X chromosomes in human embryonic stem cells (Diaz Perez et al.).
· Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.).
· Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Resources and Publications
Educational Materials (3)
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