Phorbol 12-myristate 13-acetate

PKC pathway activator; Activates protein kinase C

Phorbol 12-myristate 13-acetate

PKC pathway activator; Activates protein kinase C

From: 89 USD
Catalog #
74042_C
PKC pathway activator; Activates protein kinase C

Overview

Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg). PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.). PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker).


DIFFERENTIATION
· Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.).

· Promotes hematopoietic differentiation (Clemens et al.).

IMMUNOLOGY

· Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.).

CANCER RESEARCH
· In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.).
Alternative Names
12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA
Cell Type
Cancer Cells and Cell Lines, Mesenchymal Stem and Progenitor Cells, Monocytes, T Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Cancer, Immunology, Stem Cell Biology
CAS Number
16561-29-8
Chemical Formula
C₃₆H₅₆O
"
Molecular Weight
616.8 g/mol
Purity
≥ 98%
Pathway
PKC

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
74042, 74044
Lot #
BX24678 or lower
Language
English
Catalog #
74042, 74044
Lot #
BX24679 to BX37212
Language
English
Catalog #
74042, 74044
Lot #
BX37576 or higher
Language
English
Document Type
Safety Data Sheet
Catalog #
74042, 74044
Lot #
All
Language
English

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