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Human Recombinant Noggin (CHO-expressed)

Noggin

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Human Recombinant Noggin (CHO-expressed)

Noggin

From: 135 USD
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Noggin
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Overview

Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi et al.). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause et al.), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba et al.).
Subtype
Cytokines
Alternative Names

NOG, SYM1, SYNS1

Cell Type
Neural Cells, PSC-Derived, Neurons, Pluripotent Stem Cells
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant Noggin was tested by its ability to inhibit BMP-4 induced alkaline phosphatase production of ATDC-5 cells. Inhibitition of BMP-4 induced alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which inhibition of alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 1.9 ng/mL.
(B) 2 μg of Human Recombinant Noggin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Noggin has a predicted molecular mass of 30 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant Noggin (CHO-expressed)
Catalog #
78060.1, 78060, 78060.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant Noggin (CHO-expressed)
Catalog #
78060.1, 78060, 78060.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
hPSC Differentiation: Tools for Pluripotent Stem Cell-Derived Research
Brochure
hPSC Differentiation: Tools for Pluripotent Stem Cell-Derived Research
Products for Human Pluripotent Stem Cells
Brochure
Products for Human Pluripotent Stem Cells

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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