Human Recombinant Noggin

Noggin

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Noggin
From: 111 USD

Overview

Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi et al.). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause et al.), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba et al.).
Alternative Names:
NOG, SYM1, SYNS1, Symphalangism 1 (proximal), Synostoses (multiple) syndrome
Cell Type:
Pluripotent Stem Cells; Neurons; Neural Cells, PSC-Derived
Species:
Human
Area of Interest:
Stem Cell Biology; Neuroscience
Molecular Weight:
30 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant Noggin was tested by its ability to inhibit BMP-4 induced alkaline phosphatase production of ATDC-5 cells. Inhibitition of BMP-4 induced alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which inhibition of alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 1.9 ng/mL.
(B) 2 μg of Human Recombinant Noggin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Noggin has a predicted molecular mass of 30 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.