Human Recombinant Noggin

Noggin

Human Recombinant Noggin

Noggin

From: 120 USD
Catalog #
78060_C
Noggin

Overview

Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi et al.). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause et al.), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba et al.).
Subtype
Cytokines
Alternative Names
NOG, SYM1, SYNS1, Symphalangism 1 (proximal), Synostoses (multiple) syndrome
Cell Type
Neural Cells, PSC-Derived, Neurons, Pluripotent Stem Cells
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Molecular Weight
30 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant Noggin was tested by its ability to inhibit BMP-4 induced alkaline phosphatase production of ATDC-5 cells. Inhibitition of BMP-4 induced alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which inhibition of alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 1.9 ng/mL.
(B) 2 μg of Human Recombinant Noggin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Noggin has a predicted molecular mass of 30 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78060, 78060.1, 78060.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78060, 78060.1, 78060.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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