Papain

For digestion of the extracellular matrix of cartilage

Papain

For digestion of the extracellular matrix of cartilage

From: 60 USD
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For digestion of the extracellular matrix of cartilage
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Product Advantages


  • Degrades protein substrates more effectively than other pancreatic proteases, while minimizing cell damage.


Overview

Degrade protein substrates effectively while minimizing cell damage with Papain. This cysteine protease has a wide specificity, but has a preference for arginine, lysine, and phenylalanine. Native crystalline papain is unreactive until acted upon by mild reducing agents, e.g., cysteine, sulfide, or sulfite, and therefore likely exists as a zymogen. Compared to other pancreatic proteases, this enzyme facilitates more extensive degradation of protein substrates, such as the intercellular matrix proteins in cartilage. It is typically less damaging and more effective than other proteases for tissue dissociation applications (Huettner & Baugham; Lam). Papain has also been used for the digestion of neural tissue (Fasano et al.).
Subtype
Enzymatic
Alternative Names
Papainase; Papaya peptidase I
Cell Type
Dopaminergic Neurons, Mesenchymal Cells, PSC-Derived, Neurons, Pancreatic Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Cell Culture
Area of Interest
Cancer, Neuroscience, Stem Cell Biology

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
Papain
Catalog #
07466, 07465
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Papain
Catalog #
07466, 07465
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.