Mouse Recombinant IL-6

Interleukin 6
Catalog #
78052_C
Interleukin 6
From: 185 USD

Overview

Interleukin 6 (IL-6) is a pleiotropic growth factor with a wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Nordan et al.; Van Snick et al.; Gauldie et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of the JAK/STAT signaling pathway (Mihara et al.; Peters et al; Tanaka et al.).
Subtype
Cytokines
Alternative Names
B cell differentiation factor, BSF-2, IFN-β2, Interleukin-6
Cell Type
Airway Cells, B Cells, Hematopoietic Stem and Progenitor Cells, Intestinal Cells, Lymphocytes, Neurons, Pluripotent Stem Cells, T Cells
Species
Mouse
Area of Interest
Epithelial Cell Biology, Immunology, Neuroscience, Stem Cell Biology
Molecular Weight
21.9 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet 1
Product Name
Mouse Recombinant IL-6
Catalog #
78052, 78052.1
Lot #
BX25867 and lower
Language
English
Document Type
Product Information Sheet 2
Product Name
Mouse Recombinant IL-6
Catalog #
78052, 78052.1
Lot #
Lot BX26012 and BX26091
Language
English
Document Type
Product Information Sheet 3
Product Name
Mouse Recombinant IL-6
Catalog #
78052, 78052.1
Lot #
Lot BX26409 and higher
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant IL-6
Catalog #
78052, 78052.1
Lot #
All
Language
English

Educational Materials (3)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-6 was tested by its ability to promote the proliferation of 7TD1 cells. Cell proliferation was measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 2.4 - 3.6 pg/mL.
(B) 1 μg of Mouse Recombinant IL-6 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-6 has a predicted molecular mass of 21.9 kDa.

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