Human Recombinant TGF-beta 2

Transforming growth factor beta 2
Catalog #
78174_C
Transforming growth factor beta 2
From: 206 USD

Overview

Transforming growth factor (TGF) beta 2 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. Similar to TGF-β1 & -β3, TGF-β2 signals via serine-threonine kinase type I and II receptors and activates signal transduction via SMAD family proteins, regulating a variety of functions such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism (de Caestecker; Massague; Zuniga et al.). TGF-β2 is important in many developmental processes; for example, mice with TGF-β2 deletions show defects in the development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems (Dunker & Kreiglstein).
Subtype
Cytokines, Growth Factors
Alternative Names
BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, TGF-beta-2, TGFB2, Transforming growth factor beta-2
Cell Type
Airway Cells, Mesenchymal Cells, PSC-Derived, Mesenchymal Stem and Progenitor Cells
Species
Human
Area of Interest
Respiratory Research, Stem Cell Biology
Molecular Weight
12.7 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant TGF-beta 2
Catalog #
78174
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant TGF-beta 2
Catalog #
78174
Lot #
All
Language
English

Educational Materials (7)

Brochure
Reliable Antibodies for Your Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
The Identity and Properties of Mesenchymal Stem Cells
Scientific Poster
PneumaCult™-Ex Plus, a Novel Defined and Feeder-Free Medium, Supports the Improved Expansion of Primary Human Airway Epithelial Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant TGF-beta 2 was tested by its ability to promote the proliferation of mouse HT-2 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.2 ng/mL. (B) 5 μg of Human Recombinant TGF-beta 2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant TGF-beta 2 has a predicted molecular mass of 12.7 kDa.

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