Human Recombinant IL-7, ACF

Interleukin 7, animal component-free

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Interleukin 7, animal component-free
From: 206 USD

Overview Related Products Scientific Resources Product Applications Data and Publications

Overview

Interleukin 7 (IL-7) is a member of the type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and regulatory T cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige). This product is animal component-free.
Alternative Names:
Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Cell Type:
Hematopoietic Stem and Progenitor Cells
Species:
Human
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
17.5 kDa
Purity:
≥ 95%

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language
Product Information Sheet
Human Recombinant IL-7, ACF
78196, 78196.1, 78196.2
All
EN
Safety Data Sheet
Human Recombinant IL-7, ACF
78196, 78196.1, 78196.2
All
English

Educational Materials

(4)
Brochure
Complete Antibody Listing
Brochure
Cytokines, Chemokines and Growth Factors
Brochure
ELISA Kits for Immunology Research
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area Workflow Stages for
Workflow Stages
Hematopoietic Stem and Progenitor Cell Research
Cell Sourcing and Isolation
Expansion and Differentiation
Analysis
Total Lymphocyte Research
Cell Sourcing
Cell Isolation
Cell Characterization
T Cell Research
Cell Sourcing
Cell Isolation
Cell Activation and Expansion
Cell Characterization
T Cell Engineering
Cell Isolation
Cell Activation and Expansion
Cell Characterization
Cell Cryopreservation

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-7, ACF was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.769 ng/mL. (B) 1 μg of Human Recombinant IL-7, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7, ACF has a predicted molecular mass of 17.5 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.