Human Recombinant IL-5

Interleukin 5
Catalog #
78048_C
Interleukin 5
From: 185 USD

Overview

Interleukin 5 (IL-5) is a member of the short-chain 4-α-helical bundle subset of hematopoietic cytokines. It binds to a receptor consisting of IL-5Ra, which is specific for IL-5R, and common beta chain, which is shared with the receptor for IL-3 and GM-CSF (Shearer). Upon binding to its receptor, IL-5 activates the JAK/STAT and MAPK pathways. IL-5 is produced by Th2 cells, eosinophils, and activated mast cells. It functions in the recruitment, activation, proliferation, and survival of eosinophils, thus playing an important role in allergic inflammation, asthma, and parasite immunity. Stimulation of eosinophils with IL-5 leads to their activation, upregulation of CD11b expression, and inhibition of apoptosis (Shearer).
Subtype
Cytokines
Alternative Names
B cell differentiation factor II, BCDFII, EDF, Eosinophil differentiation factor, Interleukin-5, TFR
Cell Type
B Cells, Granulocytes and Subsets, Hematopoietic Stem and Progenitor Cells
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
26.6 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-5
Catalog #
78048.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-5
Catalog #
78048.1
Lot #
All
Language
English

Educational Materials (3)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-5 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 62 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.13 - 0.2 ng/mL.
(B) 1 μg of Human Recombinant IL-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-5 is a homodimer of 13.3 kDa subunits and has a predicted total molecular mass of 26.6 kDa.

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