Mouse Recombinant IL-5

Interleukin 5
Catalog #
78049_C
Interleukin 5
From: 187 USD

Overview

Interleukin 5 (IL-5) is a member of the short-chain 4-α-helical bundle subset of hematopoietic cytokines. It binds to the specific α receptor, which in turn recruits the common β receptor that initiates signaling via JAK/STAT and MAPK pathways. IL-5 is produced by Th2 cells, eosinophils, activated mast cells, and ILC2 cells. IL-5 affects the differentiation, activation, and survival of eosinophils, thus playing an important role in allergic inflammation, asthma, and parasite immunity. Stimulation of eosinophils with IL-5 leads to their activation, upregulation of CD11b expression, and inhibition of apoptosis (Shearer).
Subtype
Cytokines
Alternative Names
B cell differentiation factor II, BCDFII, EDF, Eosinophil differentiation factor, Interleukin-5, TFR
Cell Type
B Cells, Granulocytes and Subsets, Hematopoietic Stem and Progenitor Cells
Species
Mouse
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
26.3 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant IL-5
Catalog #
78049.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant IL-5
Catalog #
78049.1
Lot #
All
Language
English

Educational Materials (3)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Tools For Your Immunology Research
Wallchart
Human Immune Cytokines

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-5 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 70 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.15 - 0.22 ng/mL.
(B) 1 μg of Mouse Recombinant IL-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-5 has a predicted molecular mass of 26.3 kDa.

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