Mouse Recombinant IL-5

Interleukin 5

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Interleukin 5
From: 202 USD

Overview

Interleukin 5 (IL-5) is a member of the short-chain 4-α-helical bundle subset of hematopoietic cytokines. It binds to the specific α receptor, which in turn recruits the common β receptor that initiates signaling via JAK/STAT and MAPK pathways. IL-5 is produced by Th2 cells, eosinophils, activated mast cells, and ILC2 cells. IL-5 affects the differentiation, activation, and survival of eosinophils, thus playing an important role in allergic inflammation, asthma, and parasite immunity. Stimulation of eosinophils with IL-5 leads to their activation, upregulation of CD11b expression, and inhibition of apoptosis (Shearer).
Alternative Names:
B cell differentiation factor II, BCDFII, EDF, Eosinophil differentiation factor, Interleukin-5, TFR
Cell Type:
Hematopoietic Stem and Progenitor Cells; Granulocytes and Subsets; B Cells
Species:
Mouse
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
26.3 kDa
Purity:
≥ 95%

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(3)

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-5 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 70 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.15 - 0.22 ng/mL.
(B) 1 μg of Mouse Recombinant IL-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-5 has a predicted molecular mass of 26.3 kDa.

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