Genome Editing of Hematopoietic Stem and Progenitor Cells

CRISPR-Cas9 genome editing of human hematopoietic stem and progenitor cells (HSPCs) has advanced our understanding of the mechanisms that regulate hematopoiesis and is contributing to the development of novel cellular therapies. However, genome editing of HSPCs can be challenging due to inefficient delivery and expression of the CRISPR-Cas9 components. Explore the protocols and resources below for support on how to perform high-efficiency genome editing of HSPCs in your own lab.