Human Recombinant FGF-8B, ACF

Fibroblast growth factor 8B, animal component-free
Catalog #
78204_C
Fibroblast growth factor 8B, animal component-free
From: 204 USD

Overview

Fibroblast growth factor 8B (FGF-8B) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman & Klagsbrun; Kimelman & Kirschner) and are involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman & Klagsbrun; Klagsbrun; Rifkin & Moscatelli). FGF-8B signals through FGF receptors (FGFRs) to activate PI3K and MAPK pathways. FGF-8B regulates gastrulation, epithelial-mesenchymal transition, and mesenchymal to epithelial differentiation during embryonic development. FGF-8B has also been found in peripheral blood leukocytes and healthy bone marrow samples (Mattila & Härkönen). FGF-8B has mitogenic effects on somatic cells in the germinal epithelium and is expressed in adult mouse ovarian cells and tissues, which suggests that it regulates maturation of oocytes and seminiferous epithelium in testes (Valve et al.). This product is animal component-free.
Subtype
Cytokines, Growth Factors
Alternative Names
AIGF, Androgen-induced growth factor, FGF-8, Fibroblast growth factor-8B, HBGF-8, Heparin-binding growth factor-8
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Neural Cells, PSC-Derived, Pluripotent Stem Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
22.5 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant FGF-8B, ACF
Catalog #
78204, 78204.1
Lot #
BX33850 or lower
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant FGF-8B, ACF
Catalog #
78204, 78204.1
Lot #
All other lots
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-8B, ACF
Catalog #
78204, 78204.1
Lot #
All
Language
English

Educational Materials(5)

Brochure
Reliable Antibodies for Your Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Cell-Reprogramming Technology and Neuroscience
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-8B, ACF was tested by its ability to promote the proliferation of NR6R 3T3 cells in the presence of heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.915 ng/mL. (B) 1 μg of Human Recombinant FGF-8B, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-8B, ACF has a predicted molecular mass of 22.5 kDa.

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