MLN4924

Inhibits NEDD8-activating enzyme

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Inhibits NEDD8-activating enzyme
From: 130 USD

Overview

MLN4924 inhibits cullin neddylation by directly targeting the NEDD8-activating enzyme that is essential for the activity of cullin-RING ligase (CRL) (Nawrocki et al.). The components of CRL are frequently up-regulated in human cancers (Zhao & Sun), and MLN4924 was reported to suppress the growth of human tumor xenografts in mice (Soucy et al.).


GENOME EDITING
· In combination with other small molecules (“CRISPY” mix), MLN4924 has been reported to increase precise CRISPR-Cas9 genome editing in human pluripotent stem cells (Riesenberg & Maricic).

CANCER RESEARCH
· By blocking NAE and proteasome, MLN4924 together with bortezomib inhibits AKT and mTOR and induces apoptosis in multiple myeloma cell lines (Gu et al.).
Alternative Names:
Pevonedistat
CAS Number:
905579-51-3
Chemical Formula:
C₂₁H₂₅N₅O₄S
Molecular Weight:
443.5 g/mol
Purity:
≥ 98%

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.