Kenpaullone
WNT pathway activator; Inhibits GSK3ß
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Overview
REPROGRAMMING
· Replaces Klf4 in the generation of induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) transduced with Oct4, Sox2, and c-Myc (Lyssiotis et al.).
DIFFERENTIATION
· Enhances neuronal differentiation in rat and human neural precursor cell cultures (Castelo-Branco et al.; Lange et al.).
· Promotes survival of motor neurons derived from mouse embryonic stem (ES) cells and from Amyotrophic Lateral Sclerosis (ALS) patient iPS cells (Yang et al.).
CANCER RESEARCH
· Inhibits KLF4 expression and self-renewal in breast cancer stem cells in vitro (Yu et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
Publications (8)
Abstract
Abstract
Abstract
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.