· Replaces Klf4 in the generation of induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) transduced with Oct4, Sox2, and c-Myc (Lyssiotis et al.).
· Enhances neuronal differentiation in rat and human neural precursor cell cultures (Castelo-Branco et al.; Lange et al.).
· Promotes survival of motor neurons derived from mouse embryonic stem (ES) cells and from Amyotrophic Lateral Sclerosis (ALS) patient iPS cells (Yang et al.).
· Inhibits KLF4 expression and self-renewal in breast cancer stem cells in vitro (Yu et al.).
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