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Human Recombinant IL-10, ACF

Interleukin 10, animal component-free

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Human Recombinant IL-10, ACF

Interleukin 10, animal component-free

From: 1,259 USD
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Interleukin 10, animal component-free
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Overview

Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4 T cells, as well as mast cells, NK cells, neutrophils, and B cells, under specific stimulating conditions (Saraiva & O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes, and is important for the function of T regulatory cells. IL-10 also enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression, while IL-10 produced by macrophages inhibits activation of neighboring macrophages, thus allowing a level of self-regulation (Ouyang et al.). This product is animal component-free.
Subtype
Cytokines
Alternative Names

BTCGF, CSIF, Cytokine synthesis inhibitory factor, Interleukin10, TGIF

Cell Type
Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Myeloid Cells, Neurons, T Cells
Species
Human
Area of Interest
Immunology, Neuroscience, Stem Cell Biology
Formulation Category
Animal Component-Free
Purity
≥ 97%

Data Figures

(A) The biological activity of Human Recombinant IL-10, ACF was tested by its ability to promote the proliferation of MC/9 cells in the presence of human IL-4. Cell proliferation was measured after 48 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 1.95 ng/mL. (B) 1 μg of Human Recombinant IL-10, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-10, ACF
Catalog #
78144.1, 78144.2, 78144
Lot #
1000077365 or lower
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant IL-10, ACF
Catalog #
78144.1, 78144.2, 78144
Lot #
1000077366 or higher
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-10, ACF
Catalog #
78144.1, 78144.2, 78144
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (5)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Frequencies of Human Cell Types in Blood-Related Sources
Wallchart
Frequencies of Human Cell Types in Blood-Related Sources
Human Immune Cytokines
Wallchart
Human Immune Cytokines
Cell Isolation Directly from Whole Blood without RBC Lysis or Centrifugation: EasySep™ Direct
1:44
Video
Cell Isolation Directly from Whole Blood without RBC Lysis or Centrifugation: EasySep™ Direct

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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