DBZ
Notch pathway inhibitor; Inhibits γ-secretase
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Overview
REPROGRAMMING
· Enables reprogramming of human keratinocytes to induced pluripotent stem cells in the absence of oncogenic reprogramming factors KLF4 and c-MYC (Ichida et al.).
DIFFERENTIATION
· Induces intestinal cell apoptosis & goblet cell metaplasia in rats; attenuates the reduction of paneth cells and goblet cells caused by tuberous sclerosis 2 (TSC2) inhibition (Milano et al.; Zhou et al.).
METABOLISM
· Improves glucose homeostasis and mediates a metabolic shift toward the utilization of fat as the energy source in mice (Bi et al.).
CANCER RESEARCH
· Induces differentiation of intestinal adenomas in Apc(Min) transgenic mice (van Es et al.).
· Decreases the production of inflammatory cytokines by alloreactive T cells after bone marrow transplantation in mice, reducing the severity of graft-versus-host disease (Tran et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (3)
Publications (9)
Abstract
Abstract
Abstract
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.