Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)

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Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)

500 µg
Catalog #74242
399 USD

Overview

Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).


MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).

CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
Alternative Names:
NSC 381866
CAS Number:
88899-55-2
Chemical Formula:
C₃₅H₅₈O₉
Molecular Weight:
622.8 g/mol
Purity:
≥ 95%

Scientific Resources

Product Documentation

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Product Applications

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.