(±)-Flurbiprofen
PI3K/AKT pathway inhibitor; Inhibits COX-1 and COX-2
Overview
(±)-Flurbiprofen is a cell-permeable and non-steroidal anti-inflammatory agent. It is a potent non-selective inhibitor of cyclooxygenase (COX) with EC50 = 0.1 and 0.4 µM for the inhibition of recombinant human COX-1 and COX-2, respectively (Gierse et al.).
MAINTENANCE AND SELF-RENEWAL
· Maintains self-renewal and pluripotency in hESC cells grown in conditions that induce differentiation (Bhanu et al.; Desbordes et al.).
CANCER RESEARCH
· Inhibits tumor growth in models of prostate cancer, familial adenomatous polyposis, and brain cancer (King, Jr & Khalili; Grubbs et al.; Wechter et al.; Zemskova et al.).
MAINTENANCE AND SELF-RENEWAL
· Maintains self-renewal and pluripotency in hESC cells grown in conditions that induce differentiation (Bhanu et al.; Desbordes et al.).
CANCER RESEARCH
· Inhibits tumor growth in models of prostate cancer, familial adenomatous polyposis, and brain cancer (King, Jr & Khalili; Grubbs et al.; Wechter et al.; Zemskova et al.).
Alternative Names
Ansaid
Cell Type
Brain Tumor Stem Cells, Cancer Cells and Cell Lines, Prostate Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance
Area of Interest
Cancer, Disease Modeling, Neuroscience
CAS Number
5104-49-4
Chemical Formula
C₁₅H₁₃FO₂
"Molecular Weight
244.3 g/mol
Purity
≥ 99%
Pathway
PI3K/AKT
Target
COX-1
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
(±)-Flurbiprofen
|
Catalog #
73924 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
(±)-Flurbiprofen
|
Catalog #
73924 |
Lot #
All |
Language
English |
Educational Materials (3)
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Legal Statement:
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
