Human Recombinant IP-10 (CXCL10)

Interferon gamma-inducible protein 10

Human Recombinant IP-10 (CXCL10)

Interferon gamma-inducible protein 10

From: 349 USD
Catalog #
78165_C
Interferon gamma-inducible protein 10

Overview

Interferon gamma-inducible protein (IP) 10 or CXCL10 is a member of the CXC chemokine family. It binds CXCR3 activating ERK1/2, p38/MAPK, JNK, and PI3-kinase/AKT signaling pathways, inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis. IP-10 regulates innate and adaptive immune responses by affecting the function of activated T cells, natural killer cells, inflammatory dendritic cells, macrophages, and B cells. IP-10 is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to IFN-gamma. IP-10 has been implicated in a wide range of diseases, including infectious diseases and chronic inflammatory and autoimmune diseases, as well as in tumor formation (Liu et al.).
Subtype
Cytokines
Alternative Names
10 kDa interferon-gamma-induced protein, C7, crg-2, Chemokine (C-X-C motif) ligand 10, CXCL10, Gamma-IP-10, gIP-10, IFI10, INP10, mob1, SCYB10, Small inducible cytokine B10
Cell Type
Monocytes, T Cells
Species
Human
Area of Interest
Immunology
Molecular Weight
8.8 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IP-10 (CXCL10) was tested using a Ca2+ mobilization assay in CHO-K1 stably expressing Gα15 and CXCR3. Calcium mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which calcium mobilization is at 50% of maximum. The EC50 in the example above is less than 0.2 μg/mL. (B) 2 μg of Human Recombinant IP-10 (CXCL10) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IP-10 (CXCL10) has a predicted molecular mass of 8.8 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78165.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78165.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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