Dibutyryl-cAMP
cAMP pathway activator; Activates cAMP-dependent protein kinases
Overview
Dibutyryl-cAMP is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP-dependent protein kinases (Schwede et al.). This product is supplied as the sodium salt of the molecule.
DIFFERENTIATION
· Suppresses experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells in the subventricular zone towards the demyelinated plaques (Khezri et al.).
· Induces intrinsic axon growth in peripheral and central nervous systems, and morphological differentiation of astrocytes (Knott et al.; Imamura & Ozawa).
· Stimulates neurite outgrowth in PC12 cells (Maruoka et al.).
DIFFERENTIATION
· Suppresses experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells in the subventricular zone towards the demyelinated plaques (Khezri et al.).
· Induces intrinsic axon growth in peripheral and central nervous systems, and morphological differentiation of astrocytes (Knott et al.; Imamura & Ozawa).
· Stimulates neurite outgrowth in PC12 cells (Maruoka et al.).
Alternative Names
Bucladesine; DC 2797
Cell Type
Astrocytes, Neural Cells, PSC-Derived, Neurons
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Expansion
Area of Interest
Disease Modeling, Neuroscience
CAS Number
16980-89-5
Chemical Formula
C₁₈H₂₃N₅O₈P · Na
Molecular Weight
491.4 g/mol
Purity
≥ 95%
Pathway
cAMP
Target
cAMP-Dependent Kinase
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Dibutyryl-cAMP (Sodium Salt)
Catalog #
73882, 73884, 73886, 100-0244 Lot #
All Language
English Document Type
Safety Data Sheet
Product Name
Dibutyryl-cAMP (Sodium Salt)
Catalog #
73882, 73884, 73886 Lot #
All Language
English Document Type
Safety Data Sheet
Product Name
Dibutyryl-cAMP (Sodium Salt)
Catalog #
100-0244 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for
hPSC-Derived Neural Cell Research
Workflow Stages for
Neural Stem and Progenitor Cell Research
Resources and Publications
Educational Materials (3)
Related Products
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Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
