Semi-Solid Cloning with ClonaCell™
Cloning hybridomas and CHO cells can be done faster and more efficiently using semi-solid cloning, compared to traditional cloning techniques. During semi-solid cloning, individual cells are immobilized within a viscous, semi-solid medium and grow into discrete, monoclonal colonies. Picking these colonies enables isolation of a large number of diverse clones with a high probability of monoclonality. Semi-solid cloning reduces or eliminates empty cloning wells, allowing more clones to be isolated using fewer resources. Semi-solid cloning also facilitates easy isolation of both fast- and slow-growing clones, thus increasing clonal diversity and making it easier to find rare, high-producing or functional clones.
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