· As a component of a neural reprogramming cocktail, SMER28 reprograms mouse fibroblasts into induced neural stem cell-like cells (Zhang et al.).
· Enhances clearance of autophagy substrates including mutant huntingtin in Huntington's disease and A53T α-synuclein in familial Parkinson's disease (Sarkar et al.).
· Through autophagy factor ATG5, stimulates erythropoiesis and up-regulates expression of globin genes in both in vitro and in vivo models of Diamond-Blackfan anemia (Doulatov et al.).
· Decreases the level of indicators of Alzheimer's disease (amyloid-β peptide and the amyloid precursor protein [APP]-derived fragment) via the autophagy-related protein 5-dependent pathway (Tian et al.).
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