SMER28

Enhances mammalian autophagy

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Enhances mammalian autophagy
From: 55 USD

Overview

SMER28, a bromo-substituted quinazoline, was first identified as a small-molecule enhancer of rapamycin (SMER; Sarkar et al.). SMER28 induces autophagy by increasing autophagosome synthesis and enhancing the clearance of model autophagy substrates (Renna et al.).


REPROGRAMMING
· As a component of a neural reprogramming cocktail, SMER28 reprograms mouse fibroblasts into induced neural stem cell-like cells (Zhang et al.).

DISEASE MODELING
· Enhances clearance of autophagy substrates including mutant huntingtin in Huntington's disease and A53T α-synuclein in familial Parkinson's disease (Sarkar et al.).
· Through autophagy factor ATG5, stimulates erythropoiesis and up-regulates expression of globin genes in both in vitro and in vivo models of Diamond-Blackfan anemia (Doulatov et al.).
· Decreases the level of indicators of Alzheimer's disease (amyloid-β peptide and the amyloid precursor protein [APP]-derived fragment) via the autophagy-related protein 5-dependent pathway (Tian et al.).
Alternative Names:
Not applicable
CAS Number:
307538-42-7
Chemical Formula:
C₁₁H₁₀BrN₃
Molecular Weight:
264.1 g/mol
Purity:
≥ 98%

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.