SMER28
Overview
REPROGRAMMING
· As a component of a neural reprogramming cocktail, SMER28 reprograms mouse fibroblasts into induced neural stem cell-like cells (Zhang et al.).
DISEASE MODELING
· Enhances clearance of autophagy substrates including mutant huntingtin in Huntington's disease and A53T α-synuclein in familial Parkinson's disease (Sarkar et al.).
· Through autophagy factor ATG5, stimulates erythropoiesis and up-regulates expression of globin genes in both in vitro and in vivo models of Diamond-Blackfan anemia (Doulatov et al.).
· Decreases the level of indicators of Alzheimer's disease (amyloid-β peptide and the amyloid precursor protein [APP]-derived fragment) via the autophagy-related protein 5-dependent pathway (Tian et al.).
Scientific Resources
Product Documentation
Document Type | Product Name | Catalog # | Lot # | Language |
---|---|---|---|---|
Document Type
Product Information Sheet
|
Product Name
SMER28
|
Catalog #
74202, 74204 |
Lot #
All |
Language
English |
Document Type
Safety Data Sheet
|
Product Name
SMER28
|
Catalog #
74202, 74204 |
Lot #
All |
Language
English |
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.